Do you have to have a whirlpool bathtub or a walk-in closet? Will you be entertaining and thus in need of a dining table that can seat six or eight? Do you want benefits like priority dinner reservations and being first in line to get on or off the ship? Do you want to be pampered with extra-plush linens and bathrobes, fancy bath products and in-suite coffee and booze? You can find those amenities and more in most of the upper-level suites.
Exception: Royal Caribbean and other cruise lines will also use sub categories to distinquish between how many occupants the cabin will sleep. Therefore a cabin that can sleep up to 4 people will be a different sub category from a cabin that sleeps only 2 people.
Having a personal butler can be a wonderfully pampering experience, and some cruise lines include the butler service as part of your fare when you select a suite or "concierge level" cabin. Look carefully at the difference in the cruise fare, and decide if it is really worth it. Beyond that, look at the services that are offered; some cruise line butlers really do provide extra value. For instance, some can bring you room service from hard-to-get-into alternative restaurants, refill your mini-bar to personal specifications, and serve in-cabin meals course-by-course. Butlers can also unpack and repack your bags, draw rose-petal baths and assist you in preparing in-suite cocktail parties.
For some reason, most cruise lines assign their nicest and most expensive cabins to the highest decks, usually just below the pool deck (most likely because if you have a window or balcony, you have a more sweeping vista). Still, it is the pool deck that often causes the most noise problems, so if you do not want to hear scraping chairs at the crack of dawn or yee-hawing pool parties until the wee hours, go down a level. In fact, when it comes to noise, the best bet is to select a cabin that is both above and below other cabins.