Some cruise travelers prefer their cabins to be near to (or far away from) specific areas of the ship. Sun-worshippers might prefer an upper-deck location close to the pools and sun decks, while partiers might want easy access to midship entertainment hubs. Travelers with mobility concerns may prefer a stateroom close to a bank of elevators.
If you tend to get seasick, cabin location is really important. It is a question of engineering, really. The lower and more central you are in a ship, the less roll and sway you will feel. Even if you choose a balconied stateroom, choose the lowest level and the most midship one you can find. The higher decks and cabins at the very front (forward) or back (aft) of the ship will rock and roll the most.
Cabins are priced based on location on the ship. Typically cabins on lower decks are less expensive. Typically cabins midship (in the middle part of a deck) cost higher. Balcony and Suite cabins on the very aft of the ship can also be more expensive than other cabins.
Some lines offer gated-access suite complexes where some of the most expensive accommodations are arranged around exclusive deck areas, including private pools, whirlpools, fitness centers, sun decks, restaurants and lounges; MSC Cruises Yacht Club and Norwegian s Haven are two examples. Norwegian s studio cabins -- although tiny inside affairs -- also gain you access to a special lounge reserved just for solo travelers.